11th June 2025

Explanation: 
The Coalition for Disaster Resilient Infrastructure (CDRI) is a partnership of national governments, UN agencies and programmes, multilateral development banks and financing mechanisms, the private sector, and knowledge institutions that aims to promote the resilience of new and existing infrastructure systems to climate and disaster risks in support of sustainable development. CDRI promotes rapid development of resilient infrastructure to respond to the Sustainable Development Goals’ imperatives of expanding universal access to basic services, enabling prosperity and decent work. Enhancing nationally and regionally appropriate standards, codes, specifications and guidelines for the planning, design, operation and maintenance of infrastructure systems. Enhancing capacities and practices to reduce infrastructure damages and losses and consequent interruption of basic services and economic activity, from disasters and climate change. 

Explanation: 
Both government and private hospitals must report births and deaths to the registrar under the CRS. Registration duties vary across states—Health Departments handle it in some states, while Panchayat Departments (e.g., Kerala) and the Directorate of Economics and Statistics (e.g., Bihar) manage it in others. The 2023 amendment mandates digital registration through the central CRS portal. Chief Registrars and Registrars must share data with the RGI’s central database. 

Explanation: 
Magnetic Isolation and Concentration cryo-electron microscopy helps researchers to study samples 100 times more dilute than before. It is a technique enabling direct structural analysis of targets captured on magnetic beads, thereby reducing the targets’ concentration requirement to <0.0005 mg/mL. Working — It uses magnetic beads (50-nm size beads) to hold molecules in place. This greatly reduces the amount of protein needed in the initial sample. A refined analysis method called Duplicated Selection To Exclude Rubbish (DuSTER) was designed in parallel to help capture the structure of smaller molecules. MagIC-cryo-EM and DuSTER will allow scientists to use cryo-EM to examine the structure of proteins which are smaller, challenging to isolate or present in minute quantities inside cells. Application — The knowledge gained from these findings could help us better understand a wide range of biological processes. 

Explanation: 
Gaganyaan is the ₹10,000-crore Indian human space flight scheduled for 2027. It is designed to have 3-7 crew members spend 3-7 days in space in a 400-km orbit. GSLV Mk III, also called the LVM-3 (Launch Vehicle Mark-3) the three-stage heavy lift launch vehicle, will be used to launch Gaganyaan as it has the necessary payload capability. Under the Gaganyaan schedule, three flights will be sent in orbit. Of the three, there will be two unmanned flights and one human spaceflight. 

Explanation: 
Axiom Mission 4 (or Ax-4) is a private spaceflight to the International Space Station. It is operated by Axiom Space and uses a SpaceX Crew Dragon spacecraft. The flight is in collaboration with NASA and will be the fourth flight of Axiom Space after Axiom Mission 1, Axiom Mission 2 and Axiom Mission 3. Scheduled to launch in June 2025, Axiom-4 will continue the company's pioneering efforts to establish a sustainable human presence in Low Earth Orbit (LEO).