The concept of the Hayflick limit has significant implications for our understanding of:
- Ageing and age-related diseases
- Cancer development and progression
- Regenerative medicine and tissue engineering
- The potential for human lifespan extension
Select the correct answer using the code given below:
Explanation:
Statement 1 is correct. The Hayflick limit plays a crucial role in the aging process, as the accumulation of senescent cells contributes to tissue dysfunction and age-related diseases.
Statement 2 is correct. The ability of cancer cells to bypass the Hayflick limit through telomerase reactivation is a hallmark of cancer, enabling their uncontrolled proliferation.
Statement 3 is correct. The Hayflick limit poses a challenge for regenerative medicine and tissue engineering, as it limits the ability to expand cells in culture for therapeutic purposes.
Statement 4 is correct. Overcoming the Hayflick limit is a theoretical avenue for extending human lifespan, but it also raises concerns about potential negative consequences, such as increased cancer risk.
Explanation:
Statement 1 is correct. The Hayflick limit plays a crucial role in the aging process, as the accumulation of senescent cells contributes to tissue dysfunction and age-related diseases.
Statement 2 is correct. The ability of cancer cells to bypass the Hayflick limit through telomerase reactivation is a hallmark of cancer, enabling their uncontrolled proliferation.
Statement 3 is correct. The Hayflick limit poses a challenge for regenerative medicine and tissue engineering, as it limits the ability to expand cells in culture for therapeutic purposes.
Statement 4 is correct. Overcoming the Hayflick limit is a theoretical avenue for extending human lifespan, but it also raises concerns about potential negative consequences, such as increased cancer risk.
